Department of Anatomical Sciences (2017 - Present)
Anatomical sciences
Anatomical sciences, Tehran University of Medical Sciences, Tehran , Iran
Anatomical sciences
Anatomical sciences, Shiraz University of Medical Sciences, Shiraz , Iran
Midwifery
Midwifery , Shiraz University of Medical Sciences, Shiraz, Iran
Acetamiprid (ACE) is one of the widely used neonicotinoid insecticides. In mammals, in spite of the low-affinity nAChRs, neurotoxic effects following the Acetamiprid exposure have recently been reported, which suggests some concerns regarding the impacts on the nervous system of mammals. This study aims to investigate the effect of Acetamiprid on spatial memory and possible vulnerability of hippocampal glutamatergic system following the Acetamiprid exposure. 10, 20, and 40 mg/kg doses of Acetamiprid were administered to male rats by gavage once per day for 28 days. The spatial memory was examined with the Morris water maze apparatus. The amount of Acetamiprid in the serum and hippocampus was measured. In addition, glutamate level and change
BACKGROUND AND OBJECTIVE: Nicotine is one of the most common addictive substances that has many effects on the central nervous system, including dose-dependent anxiety that is mediated by various proteins. Since the mechanisms and proteins involved in nicotine anxiety are unclear, the purpose of the present study was to investigate the role of p-CREB (cAMP Response Element-Binding Protein) and c-Fos proteins in the basolateral amygdala (BLA) on nicotine-induced anxiety behaviours.METHODS: In this experimental study, 24 male Wistar rats were divided into three groups of 7 (saline, nicotine 0.3 and 0.7 mg/kg, intraperitoneally) in behavioral experiment and four groups of 3 (control: no injection and test, Saline, nicotine 0.3 and 0.7 mg/kg) i
Coronaviruses are a large family of viruses that usually cause mild to moderate upper respiratory tract illnesses. The newly emerged sever acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported in late 2019 and causes coronavirus disease 2019 (COVID-19). Due to the novelty of the virus, new scientific evidence on various aspects of COVID-19 is reported in the literature continuously. Common symptoms of COVID-19 include fever, dry cough, fatigue, myalgia, arthralgia and Shortness of breath. Some articles have also reported on various manifestations of SARS-CoV-2 infection outside the respiratory tract. The affected organs are gastrointestinal tract, central nervous system, skin, olfactory system, cardiovascular system, liver, kid
Bone marrow-derived mesenchymal stem cells (BMMSCs) transplantation has shown to be effective in treating chronic kidney disease. However, the effectiveness of this strategy is constrained by low homing and survival rate of transplanted cells in the injured organs. Therefore, developing strategies to improve homing and cell survival rate and therapeutic potential in cell-based therapies seems necessary. The purpose of this study is to evaluate the effect of pretreating BMMSCs with melatonin (MT) on the prosurvival and renoprotective of transplanted cells into the irreversible model of unilateral ureteral obstruction. Adult male Sprague–Dawley rats were randomized into four groups: Sham, UUO, UUO + BMMSCs, and UUO + BM
Minocycline as a member of tetracycline family is a lipophilic broad‐spectrum antibiotic, which can display some non‐antibiotic properties such as antioxidant, antiapoptosis, neuroprotection and modulation of pharmacological traits of drugs of abuse (ie., reward, sensitization and/or analgesia). Thus, the aim of the present study was to investigate the effect of Intracerebroventricular (ICV) injection of minocycline on morphine‐induced memory impairment and motor function in male Wistar rats. The behavioral responses were measured by passive avoidance test for evaluating memory, and open field for studying motor function. Furthermore, the expression of Phospho‐cAMP response element‐binding protein (P‐CREB) and c‐Fos were asse
Background The clinical application of methotrexate (MTX), an efficacious cytotoxic drug, is restricted due to its associated liver toxicity. Ellagic acid (EA), a natural polyphenol, possesses hepatoprotective, antioxidant and anti-inflammatory properties. Objectives The present study seeks to address the hepatoprotective effects of Ellagic acid (EA) against MTX-mediated oxidative stress (OS) and widen our current knowledge of the underlying molecular mechanisms of MTX toxicity. Methods Wistar rats were orally given EA (5?mg/kg and 10?mg/kg) for 10 successive days and at the end of the third day they were administered a single dose of MTX (20?mg/kg i.p). Results After performing biochemical analysis, liver enzymes and malondialdehyd
Background: Nowadays, transplantation of bone marrow-derived Mesenchymal Stromal Cells (BMSCs) is currently an important alternative therapy for patient’s type 1 diabetes mellitus. But a number of critical obstacles lie ahead of this new strategy including reducing stem cell homing to the damaged tissue due to oxidative stress. The purpose of the present study was to investigate whether preconditioning of BMSCs with SDF-1 could enhance their homing to the pancreas and promote regeneration of the pancreatic β cells after being intravenously injected.Methods: Mice BMSCs were isolated and expanded. Cell proliferation was assayed by MTT Assay. Preconditioning was performed with 10 ng/ml SDF-1α for 24 hr. Male NMRI mice were injected with hi
Industrial and agricultural developments in recent years have resulted in the excessive discharge of arsenic into the environment, making arsenic toxicity a major worldwide concern. Oxidative stress is considered the primary mechanism for arsenic toxicity. The main objective of this study was to evaluate acetyl-l-carnitine’s (ALC) protective ability against the arsenic-induced hepatotoxicity. For this purpose, male Wistar rats were distributed randomly into 5 groups of 8 rats each: control, arsenic (5 mg/kg) and arsenic plus ALC (5 mg/kg; 100, 200, 300 mg/kg). The animals were gavaged for 21 consecutive days. Liver tissue samples were extracted 24 h after the last treatment and were later analyzed for biochemical and histological
Objective (s):Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis. The aim of the present work is to investigate the protective effects of erythropoietin against cuprizone-induced oxidative stress.Materials and Methods:Adult male C57BL/6J mice were fed a chow containing 0.2% cuprizone for 6 weeks. After 3 weeks, mice were simultaneously treated with erythropoietin (5,000 IU/kg body weight) by daily intraperitoneal injections.Results:Our results showed that cuprizone induced oxidative stress accompanied with down-regulation of subunits of the respiratory chain complex and demyelination of corpus callosum. Erythropoietin antagonized these eff
HAJIAN MONFARED, Mahdieh et al. Inductive Role of Sustentacular Cells (Sertoli Cells) Conditioned Medium on Bone Marrow Derived Mesenchymal Stem Cells. Int. J. Morphol.[online]. 2017, vol. 35, n. 4, pp. 1597-1606. ISSN 0717-9502. http://dx. doi. org/10.4067/S0717-95022017000401597.
Objective Experimental and clinical studies suggest that oxidative stress plays an important role in the pathogenesis of multiple sclerosis. In this study, we have investigated the effects of the non-psychoactive cannabinoid cannabidiol (CBD), which exerts antioxidant effects and has recently been approved for the treatment of inflammation, pain, and spasticity associated with MS patients and in a MS mouse model, ie cuprizone-induced demyelination. Methods Adult male BL/6 mice were fed with 0.2% cuprizone for 5 weeks, which caused severe demyelination of the corpus callosum (CC). Animals were simultaneously treated with 5 mg? kg− 1 CBD by daily intra-peritoneal injections. Using immunohistochemistry and transmission electron microscope, w
Arsenic (As) is a widespread environmental contaminant present around the world in both organic and inorganic forms. Oxidative stress is postulated as the main mechanism for As-induced toxicity. This study was planned to examine the protective effect of acetyl-l-carnitine (ALC) on As-induced oxidative damage in male rats. Animals were randomly divided into four groups of control (saline), sodium arsenite (NaAsO2, 20?mg/kg), ALC (300?mg/kg), and NaAsO2 plus ALC. Animals were dosed orally for 28 successive days. Blood and tissue samples including kidney, brain, liver, heart, and lung were collected on the 28th day and evaluated for oxidative damage and histological changes. NaAsO2 exposure caused a significant lipid peroxidatio
Introduction The effect of bone marrow-derived mesenchymal stem cells (BMSCs) on asthma treatment was shown in our previous study. Several studies have shown the effect of statins on BMSC preservation and migration to sites of inflammation. In this study, the effects of simvastatin and BMSC combination therapy in an ovalbumin-induced asthma model in mouse were examined. Methods Four groups of BALB/c mice were studied including control group (animals were not sensitized), asthma group (animals were sensitized by ovalbumin), asthma?+?simvastatin group (asthmatic animals were treated with simvastatin), and asthma?+?BMSC?+?simvastatin g
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