Department of Anatomical Sciences (2000 - Present)
Anatomical sciences
Anatomical Sciences - Medical Sciences Faculty, Tarbiat Modares University, Tehran, Iran
Anatomical Sciences
Anatomical Sciences, Tarbiat Modares, Tehran, Iran
Anatomical Sciences
Anatomical Sciences, Tarbiat Modares, Tehran, Iran
Anatomical Sciences
Anatomical Sciences, Tarbiat Modares, Tehran, Iran
Anatomical Sciences
Anatomical Sciences - Medical Sciences Faculty, Tarbiat Modares University, Tehran, Iran
Physiotherapy
, Tehran University of Medical Sciences, Tehran, Iran
Name: Mansoureh Surname: Movahedin Date of Birth: 2241962 Place of Birth: Tehran-Iran Status of Marriage: Married with three children. Address: Anatomical Sciences Dept. Medical Sciences Faculty, Tarbiat Modares University P.O.Box: 14115-331 Tehran Iran
BackgroundEmbryo implantation requires appropriate communication between the blastocyst and endometrium. Recurrent implantation failure is an essential component of assisted reproductive technology. Also, miRNAs-mediated gene expression impacts the implantation process, and the down-regulation of some miRs, such as mmu-let-7a, improves this process. In the present study, we evaluated the effect of let-7a forced-suppression on the mouse implantation rate.
Ultraviolet (UV) radiation causes direct and indirect damage to the cell structure, thereby increasing the aging process. Ultraviolet B-rays (UVB)(with 280-320 nm wavelengths) cause direct damage to the skin, and the portion that reaches the epidermal cells induces biological damage [1] and the most important biological damage is inflicted by DNA damage. With UVB absorption, thymine bases in the DNA bind to adjacent thymine [2]. This evidence can affect protein synthesis. The accumulation of unrepaired damages can disrupt the cell cycle and create cell death. Moreover, these damages can sometimes destroy the cell apoptotic ability and increase the malignancies. The results depend on the type of tissue, UV dose, and its wavelength [3]. UV ra
Background: Spermatogenesis is a programmed route for germ cell proliferation and differentiation that can produce abundant numbers of spermatozoa. The antioxidants play a vital role in decreasing oxidative stress production in cells; therefore, the extraction of plants with antioxidant property can prevent cell damage. In the present study, antioxidant effects of Calligonum extract on proliferation and colonization rate of spermatogonial cells was assessed.Materials and Methods: After isolation and culturing of spermatogonial stem cells (SSCs) on neonatal mice (4-5 days old) and identification by PLZF and Oct4 markers, the therapeutic effect of Calligonum comosum extract on cells treated with H2O2 was measured. The cultured cells were divi
Background: Biological scaffolds are derived by the decellularization of tissues or organs. Various biological scaffolds, such as scaffolds for the liver, lung, esophagus, dermis, and human testicles, have been produced. Their application in tissue engineering has created the need for cryopreservation processes to store these scaffolds.Objective: The aim was to compare the two methods for prolong storage testicular scaffolds.Materials and Methods: In this experimental study, 20 male NMRI mice (8 wk) were sacrificed and their testes were removed and treated with 0.5% sodium dodecyl sulfate followed by Triton X-100 0.5%. The efficiency of decellularization was determined by histology and DNA quantification. Testicular scaffolds were stored in
ObjetivoLa introducci?n de sistemas alternativos in vivo es muy importante para los pacientes con c?ncer que son tratados con tratamiento gonadot?xico. En este estudio, examinamos la progresi?n del proceso de espermatog?nesis despu?s del trasplante de c?lulas madre espermatogoniales en condiciones de cultivo de tejidos in vivo. Materiales y m?todosSe obtuvieron c?lulas madre espermatogoniales humanas a partir de una muestra de extracciones de esperma testicular y se confirm? la caracterizaci?n de estas c?lulas mediante la detecci?n de la prote?na de dedo de cinc con leucemia promieloc?tica. Estas c?lulas, despu?s de marcarse con di-alquil indocarbocianina (DiI), se trasplantaron a test?culos de rat?n con azoospermia adulta, tratados con bus
Objective: Applications of biological scaffolds for regenerative medicine are increasing. Such scaffolds improve cell attachment, migration, proliferation and differentiation. In the current study decellularised mouse whole testis was used as a natural 3 dimensional (3D) scaffold for culturing spermatogonial stem cells.Materials and Methods: In this experimental study, adult mouse whole testes were decellularised using sodium dodecyl sulfate (SDS) and Triton X-100. The efficiency of decellularisation was determined by histology and DNA quantification. Masson’s trichrome staining, alcian blue staining, and immunohistochemistry (IHC) were done for validation of extracellular matrix (ECM) proteins. These scaffolds were recellularised through
Objective: We present a four-branch model of the dielectrophoresis (DEP) method that takes into consideration the inherent properties of particles, including size, electrical conductivity, and permittivity coefficient. By using this model, bioparticles can be continuously separated by the application of only a one-stage separation process. Materials and Methods: In this numerical study, we based the separation process on the differences in the particle sizes. We used the various negative DEP forces on the particles caused by the electrodes to separate them with a high efficiency. The particle separator could separate blood cells because of their different sizes. Results: Blood cells greater than 12 μm were guided to a special branch, which
Objective(s): Adipose-derived stem cells (ADSCs), with suitable and easy access, are multipotential cells that have the ability for differentiation into other mesodermal and transdifferentiate into neural phenotype cells. In this study, Lithium chloride (LiCl) was used for in vitro transdifferentiation of rat ADSCs into neuron-like cells (NLCs).Materials and Methods: ADSCs were isolated from the rats’ perinephric region using Dulbecco΄s Modified Eagle΄s Medium (DMEM) with Fetal Bovine Serum (FBS), cultured for 3 passages, characterized by flowcytometry and differentiation into adipogenic and osteogenic phenotypes. The ADSCs were exposed to 0.1, 0.5, 1, 1.5, 2, 5, and 10 millimolar (mM) LiCl without serum for 24 hr. The optimum dose of L
This study proposes a microfluidic device capable of separating monocytes from a type of cancer cell that is called T-cell acute lymphoblastic leukemia (RPMI-8402) in a continuous flow using negative and positive dielectrophoretic forces. The use of both the hydrodynamic and dielectrophoretic forces allows the separation of RPMI-8402 from monocytes based on differences in their intrinsic electrical properties and sizes. The specific crossover frequencies of monocytes and RPMI-8402 cells have been obtained experimentally. The optimum ranges of electrode pitch-to-channel height ratio at the cross sections with different electrode widths have been generally calculated by numerical simulations of the gradients of the electric field intensities
Introduction: Ultraviolet (UV) radiation to the skin causes oxidative damage and causes cancer in the epidermis. There seems to be a relationship between the thickening of the skin layer and the carcinogenicity. The aim of this study was to establish a rare benign skin lesion of Trichoepithelioma in an animal model and to investigate the relationship between the radiation dose of ultraviolet waves with thickening of the skin layer resulting from high-frequency ultrasound images.Materials and Methods: To investigate the skin damage process, 25 C57BL6 mice were irradiated with UVB (5 times a week for 9 weeks) with an energy density of 135, 270, 405, 540, 675, 810, 945, 1080 and 1215 J/m2, from the first week to the ninth week, respectively. T
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