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Additionally, the article shows significant overlap with an article that was simultaneously under consideration with another journal 1. The Editors therefore no longer have confidence in the reliability of the data reported in the article.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of COVID-19, is reported to increase the rate of mortality worldwide. COVID-19 is associated with acute respiratory symptoms as well as blood coagulation in the vessels (thrombosis), heart attack and stroke. Given the requirement of angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 entry into host cells, here we discuss how the downregulation of ACE2 in the COVID-19 patients and virus-induced shift in ACE2 catalytic equilibrium, change the concentrations of substrates such as angiotensin II, apelin-13, dynorphin-13, and products such as angiotensin (1-7), angiotensin (1-9), apelin-12, dynorphin-12 in the human body. Substrates accumulation ultimately induce
The main purpose of this study was to find a simple reaction condition for reproducible synthesis of water-soluble superparamagnetic iron oxide nanoparticles (SPIONs) through the co-precipitation method. For this purpose, the effect of alkali solution, working atmosphere and final reaction temperature on type, size and magnetic properties of synthesized particles were examined. The results reveal that from two different tested alkali precipitants including ammonia and 1M NaOH, samples synthesized using ammonia demonstrate proper magnetic properties, while the latter agent leads to production of nonmagnetic brown suspensions in all reaction conditions. UV-Vis and XRD showed the typical magnetite pattern for samples synthesized using ammonia
Corrigendum: Recent progress in biomedical applications of RGD-based ligand: From precise cancer theranostics to biomaterial engineering: A systematic review?… J Biomed Mater Res A. 2020;108(4):839–850. doi:10.1002/jbm.a.36862?… The author Dr. Mohsen Aipour's affiliation was earlier published as?… 1- Department of Advanced Medical Sciences and Technologies, School of Medicine, Jahrom University of Medical Sciences (JUMS), Jahrom, Iran. 2- Department of Nano Biotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran?… 1- Department of Advanced Medical Sciences and Technologies, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran. 2- Department of Nano Biotechnology, Faculty o
The design of targeted nanoparticle platforms, which induces cell death by apoptosis, can bypass the resistance mechanisms of cancer cells. In this regard, we have constructed a new cancer targeting peptide functionalized nanoparticle using gold nanoparticles (AuNPs) and Thioctic acid-DMPGTVLP peptide conjugate. Morphological analysis of the nanoparticles by TEM displayed average diameters of about 26.2 nm and 3.52 nm for AuNP core and shell, respectively. Stronger affinity toward nucleolin receptors of breast cancer cell lines (MCF-7 and T47D) observed for Thioctic acid-Peptide gold nanoparticles (TAP@AuNPs) based on IC50 values. Furthermore, the nanoparticles showed excellent hemocompatibility. Quantitative results of atomic absorption sh
Absorbable sutures are widely used in surgery. In addition to acceptable mechanical properties, the surgical sutures should exhibit favorable degradability properties. In this research, the mechanical and thermal properties, hydrophilicity, biodegradability, pH changes, and drug release profile of polylactic acid (PLA) and polyethylene glycol (PEG) alloy were examined to fabricate absorbable sutures. The test results for the mechanical properties showed that the strength of the PLA/PEG alloy decreased with increasing PEG content, leading to an increase in elongation. The differential thermal analysis indicated that the resulting material was above its glass transition temperature (Tg) at ambient temperature and was thus flexible enough. Acc
Recognizing proteins that lead to a decreased efficiency of treatment in cancer cells constitutes a main goal for biomedical and biotechnological research and applications. Establishing recombinant cells that overexpress a gene of interest stably is important for treatment studies and drug/compound screening. Survivin is an anti-apoptotic protein which can be a potential candidate for regulating cell death and survival. To investigate the association between survivin increment and apoptosis rate, survivin-reconstituted HEK (HEK-S) cell was developed as in vitro model. RT-PCR and Western blot demonstrated that survivin was constitutively overexpressed in HEK-S cells. Both morphological observation and survival assay showed that HEK-S cells w
A variety of organic nanomaterials and organic polymers are used for enzyme immobilization to increase enzymes stability and reusability. In this study, the effects of the immobilization of enzymes on organic and organic-inorganic hybrid nano-supports are compare. Immobilization of enzymes on organic support nanomaterials was reported to significantly improve thermal, p H and storage stability, acting also as a protection against metal ions inhibitory effects. In particular, the effects of enzyme immobilization on reusability, physical, kinetic and thermodynamic parameters were considered. Due to their biocompatibility with low health risks, organic support nanomaterials represent a good choice for the immobilization of enzymes. Organic nan
Chemoresistance is the leading cause of limiting long-term treatment success in cancer cells. Anticancer drugs usually kill cells through apoptosis induction and defects in this signaling pathway lead to chemoresistance. Apoptotic protease activating factor 1 regulates cellular stress evoked by chemotherapeutic agents through facilitating apoptosome assembling but can be degraded by proteasome. This study examined the role of proteasome inhibitor Bortezomib in the cytotoxic effects of Docetaxel on MCF7 cells response and its correlation with Apaf-1 expression level. MTT assay, caspase 3/7 activity assay, propidium iodide staining, adenosine triphosphate and reactive oxygen species amount measurements were utilized to demonstrate the role of